Comparision and Extract Hypoglycemic Activity Root Extract Tablet Cats (Acalypha Indica Linn) Mice the White Male Strain Ddy

Authors

  • Ms. Junaedi Polytechnic, Department of Pharmacy. Indonesia
  • Ms. Yusmaniar
  • Sujati Woro Indijah

Keywords:

Acalyphaindica, hypoglycemic activity, Extract Tablet

Abstract

The study concerning to the comparison of hypoglycemic activity of the extract and Acalypha indica Linn. Tablet in mice male ddy strain that has been conducted . The purpose of this study is to compare the hypoglycemic activity of the leaf, herb and root extract  and it’s tablets between pure extracts and extract tablets . Mice were divided into 8 groups, namely Normal Controls (KN), Glibenclamide (G) Leaf Extract (ED), Herbal Extract (EH), Root Extract (EA), Tablets Leaf Extract (TD), Herbal Extract Tablets (TH), and Tablet Root Extract (TA). Measurement of blood glucose level performed at 4 time points;  fasting blood sugar (T0), 30 minutes after the test material (T30), 30 min after glucose administration ( T30 pc) and 2 hours after glucose administration/post prandial (T120 pc). The results showed that the group of ED and EA, and TD and TH have hypoglycemic effects that differ significantly by group KN. EH and TA group had hypoglycemic effects that did not differ significantly by group KN. ED had significantly different hypoglycemic activity with EH and EA. There is no significant differences between the hypoglycemic activity of the tablets extract for all grups. Herb extract had significantly different  hypoglycemic activity with it’s tablets.

Author Biography

Ms. Junaedi, Polytechnic, Department of Pharmacy. Indonesia

Departement Of Pharmacy

References

Anonim, 2008. Tingkat Manfaat Keamanan dan Efektifitas Tanaman Obat dan Obat

Tradisional. Balai Besar Penelitian dan Pengembangan Tanaman Obat dan Obat Tradisional.

Badan Penelitian dan Pengembangan Kesehatan Departemen Kesehatan RI (in Indonesia

Language) .

Gopalakrishnan V, 2000. Antimicrobial Activity of Extrats of Acalypha indica Linn, College

of Pharmacy Sri Ramachandra College and Research Institute (Deemed University) Poror,

Chennai – 600116

Govindarajan M., et al., 2008. Antibacterial Activity o Acalypha indica L. European Review

for Medical and Pharmacological Sciences. 12, p. 299-302.

Murugan T dan Saranraj P., 2011. Antibacterial Activity of Various Solvent Extract of The

Indian Herbal Plant Acalypha indica Against Human Patogens Causing Nasocomial

Infection. International Journal of Pharmaceutical and Biological Archives: 2(5)

p. 1473-1478

Thenmozhi S dan Rajan S., 2012. Screening of Antibacterial and Phytochemical Activity of

Acalypha indica Linn. Against Isolated Respiratory Pathogens. Research in Plant Biology.

(1). p.01-06

Prihandini K, 2004. Pengaruh Pemberian Rebusan Akar Acalypha indica Linn. (Akar

Kucing Secara Oral Terhadap Kadar Asam Urat Darah Tikus Putih Jantan Yang Diinduksi

dengan Kafein. Skripsi Sarjana, Departemen Farmasi FMIPA UI (in Indonesia

Language) , Depok, Indonesia.

Pratita A, 2004. Pengaruh Rebusan Akar Tanaman Akar Kucing (Acalypha indica Linn.)

Terhadap Kadar Asam Urat Dalam Darah pada Tikus Putih Jantan Yang Diinduksi Kalium

Oksonat. Skripsi Sarjana, Departemen Farmasi FMIPA UI (in Indonesia Language), Depok.

Hartanto MD, 2006. Pengaruh Sari Fraksi Heksana, Kloroform, Etil Asetat dan Sisa Air

dari Rebusan Akar Tanaman Akar Kucing (Acalypha indica Linn.) Dosis 10,8 g/200g BB

Terhadap Kadar Asam Urat Dalam Darah Tikus Putih Jantan Yang Diinduksi Kalium

Oksonat. Skripsi Sarjana, Departemen Farmasi FMIPA UI (in Indonesia Language) , Depok.

Dwijayanto B, 2006. Pengaruh beberapa Fraksi Rebusan Akar Acalypha indica Linn. Dosis

Setara Akar Kucing 5,4 g/200 g BB Terhadap Kadar asam Urat Dalam Darah Tikus Putih

Jantan Yang Diinduksi Kalium Oksonat. Skripsi Sarjana. Departemen Farmasi FMIPA UI (in

Indonesia Language), Depok, Indonesia.

Ahmed A.K, 2005. Diuretic Activity of Acalypha indica. Dhaka University, Journal of

Pharmaceutical Science Vo. 4 No. 1 June.

Rajathi M. D, et al, 2012. Antidiabetic and antimicrobial activity of Acalypha indica Linn.

Extract. Journal of Scientific Research in Pharmacy, 1 (3).

Saha R., Ahmed A, 2011. Hypoglycemic Effect of Acalypha indica Linn Ekxtract on

Streptozotocin Induced Diabetes in Rat. International Journal of Pharmaceutical Sciences

and Research, Vol 2, Issue 11

Manisha M., et al, 2011. Antidiabetic Activity of Acalypha indica Linn. On Normal and

Alloxan Induced Diabetic Rats. International Journal of Pharmacy and Pharmaceutical

Sciences, Vol.3 (3).

Ocktarini R, 2010. Pengaruh Ekstrak Herba anting-anting (Acalypha australis L)

Terhadap Kadar Glukosa Darah Mencit Balb/C Induksi Streptozotocin (in Indonesia

Language) . Skripsi Fakultas Kedokteran Sebelas Maret Surakarta, Indonesia.

Purwaningsih E.H. et al, 2008. Neuro-protection and Neuro-therapy effect of Acalypha

indica Linn. Water Extract Ex Vivo on Musculus gastrocnemius Frog. Makara Kesehatan,

Vol. 12 No. 2: 71-76, Depok, Indonesia

Felicia., 2009. Efek Neuroterapi Ekstrak Air akar Acalypha indica Linn (Akar Kucing)

Dosis 20 mg dan 25 mg Secara Eks Vivo Pada Saraf Otot Gastroknemius Katak. Fakultas

Kedokteran Universitas Indonesia. Jakarta, Indonesia.

Junaedi, et. al., 2013. Formulasi Tablet Ekstrak Rebusan Akar, Daunt dan Herba Akar

Kucing (Acalypha indica Linn.) Dengan Metode Cetak Langsung (in Indonesian

Language) . Karya Tulis Ilmiah. Poltekkes Kemenkes Jakarta II Jurusan Farmasi, Jakarta.

Anonim, 2000. Parameter Standar Umum Ekstrak Tumbuhan Obat. Direktorat Jendral

Pengawasan Obat dan Makanan, Departemen Kesehatan Republik Indonesia Jakarta.

Ansel H.C, 2005. Pengantar Bentuk Sediaan Farmasi edisi keempat. Penerbit Universitas

Indonesia, Jakarta, Indonesia.

Siregar, C, “Pharmaceutical preparations tablet technology, Practical Basics†(in

Indonesian Language), pp 129-153, 163, 515, 2010.

Hutapea J.R, 1993. Inventaris Tanaman Obat Indonesia (II), Departemen Kesehatan

Republik Indonesia, Jakarta, Indonesia.

Simalango R, 2003. Analisis Pendahuluan Kandungan Kimia Akar dan Herba Serta Pola

Kromatogram Fraksi Etanol Ekstrak N – Heksana Herba Acalypha indica Linn. Yang

Tumbuh di Depok. Skripsi Sarjana, Departemen Farmasi FMIPA UI, Depok.

Susanti S, 2006. Isolasi dan Identifikasi Senyawa-senyawa Kimia Fraksi N – Heksana dan

Etil Asetat dari Ekstrak Etanol Akar Tanaman Acalypha indica Linn. (Akar Kucing).

Skripsi Sarjana, Departemen Farmasi FMIPA UI, Depok, Indoneisa.

Duke J., 2006. Phytochemical and Database.

http://www.ars-grin.gov/duke/onlinedatabase/acalypha indica L/listofchemical html.

Saha R., Ahmed, A, 2011. Phytochemical Constituent and Pharmacological activities

of Acalypha indica Linn. International Journal of Pharmacy and Pharmaceutical Sciences,

Vol 2 (8) : 1900-1904

Anonim, 1993, Penapisan Farmakologi, Pengujian Fitokimia dan Pengujian Klinik,

Yayasan Pengembangan Obat Bahan Alam Phyto Medika, Jakarta, Indonesia.

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Published

2014-10-15

How to Cite

Junaedi, M., Yusmaniar, M., & Indijah, S. W. (2014). Comparision and Extract Hypoglycemic Activity Root Extract Tablet Cats (Acalypha Indica Linn) Mice the White Male Strain Ddy. Asian Journal of Applied Sciences, 2(5). Retrieved from https://www.ajouronline.com/index.php/AJAS/article/view/1771

Issue

Vol. 2 No. 5 (2014): October 2014

Section

Articles

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