Doppler Echo-flowmetry of the Uterine District and Peeclampsia

Authors

  • F. Genovese
  • C. Pafumi Institute of Obstetric and Gynecological Pathology – Santo Bambino Hospital, University of Catania, Catania

Abstract

The Authors prospectively determined the uterine artery Doppler flow velocimetry between the 10th and 13th week of pregnancy in 32 women with history of HDP  (Hypertensive Disorder of Pregnancy) in the attempt to identify those at higher risk to  develop preeclampsia during the ongoing pregnancy and the need for prophylactic  pharmacological treatment. Patients with abnormal  flowmetric values (RI > 0.58)  were immediately started on aspirin 100 mg/daily followed at the 24th week by daily subcutaneous injection of low molecular weight heparin. The authors found that the average pregnancy course in terms of maternal morbidity (expressed by abnormal  blood pressure and 24 hour proteinuria) in 20 prophylactic treated patients with abnormal 1st trimester uterine artery flowmetry was better than in their previous pregnancies, however in relation to the above parameters no significant difference  was found between the patients treated and those (n =12) with normal I trimester uterine artery Doppler flowmetry who were also followed till delivery and 6 weeks post partum but not prophylactic treated. The study suggests that uterine artery flow velocimetry determination in the late first trimester of pregnancy is useful in reducing the risk of preeclampsia especially in patients with previous history of HDP allowing the prompt institution of prophylactic treatment in selected patients.

References

J. R. Barton and B. M. Sibai, “Prediction and prevention of recurrent preeclampsia,†Obstetrics and Gynecology, vol. 112, no. 2, part 1, pp. 359–372, 2008.

N. Onwudiwe, C. K. H. Yu, L. C. Y. Poon, I. Spiliopoulos, and K. H. Nicolaides, “Prediction of pre-eclampsia by a combination of maternal history, uterine artery Doppler and mean arterial pressure,†Ultrasound in Obstetrics and Gynecology, vol. 32, no. 7, pp. 877–883, 2008.

J. A. Turner, “Diagnosis and management of pre-eclampsia: an update,†International Journal of Women’s Health, vol. 2, no. 1, pp. 327–337, 2010.

D. Cudihy and R. V. Lee, “The pathophysiology of pre- eclampsia: current clinical concepts,†Journal of Obstetrics and Gynaecology, vol. 29, no. 7, pp. 576–582, 2009.

A. M. Germain, M. C. Romanik, I. Guerra et al., “Endothelial dysfunction: a link among preeclampsia, recurrent pregnancy loss, and future cardiovascular events?†Hypertension, vol. 49, no. 1, pp. 90–95, 2007.

L. Myatt and R. P. Webster, “Is vascular biology in preeclamp- sia better?†Journal of Thrombosis and Haemostasis, vol. 7, no. 3, pp. 375–384, 2009.

J. M. Roberts and K. Y. Lain, “Recent insights into the pathogenesis of pre-eclampsia,†Placenta, vol. 23, no. 5, pp. 359–372, 2002. R. A. Harris, S. K. Nish

B. Huppertz, “Placental origins of preeclampsia: challenging the current hypothesis,†Hypertension, vol. 51, no. 4, pp. 970– 975, 2008.

N. Onwudiwe, C. K. H. Yu, L. C. Y. Poon, I. Spiliopoulos, and K. H. Nicolaides, “Prediction of pre-eclampsia by a combination of maternal history, uterine artery Doppler and mean arterial pressure,†Ultrasound in Obstetrics and Gynecology, vol. 32, no. 7, pp. 877–883, 2008.

D. Cudihy and R. V. Lee, “The pathophysiology of pre- eclampsia: current clinical concepts,†Journal of Obstetrics and Gynaecology, vol. 29, no. 7, pp. 576–582, 2009.

M. D. Savvidou, A. D. Hingorani, D. Tsikas, J. C. Fro ̈lich, P. Vallance, and K. H. Nicolaides, “Endothelial dysfunction and raised plasma concentrations of asymmetric dimethylarginine in pregnant women who subsequently develop pre-eclampsia,†The Lancet, vol. 361, no. 9368, pp. 1511–1517, 2003.

Augusto HenriquesFulgeˆncioBranda ̃o,Ludmila Maria Guimara ̃es Pereiraet al. Comparative Study of Endothelial Function and
Uterine Artery Doppler Velocimetry between Pregnant Women with or without Preeclampsia Development. Journal of Pregnancy Volume 2012, Article ID 909315, 5 pages

Harrington K, Cooper D, Lees C, Hecher K, Campbell S. Doppler ultrasound of the uterine arteries: the importance of bilateral notching in the prediction of pre-eclampsia, placental abruption or delivery of a small-for-gestational-age baby. Ultrasound ObstetGynecol 1996;7:182-8

Macé G, Cynober E, Carbonne B. Ultrasound markers for the detection of women at risk of developing pre-eclampsia. ClinChem Lab Med. 2011 Dec 13.

Carbillon L. First trimester uterine artery Doppler for the prediction of preeclampsia and foetal growth restriction.JMatern Fetal Neonatal Med. 2011 Aug 30.

Bodova KB, Biringer K, Dokus K, Ivankova J, Stasko J, Danko J.Fibronectin, plasminogen activator inhibitor type 1 (PAI-1) and uterine arteryDoppler velocimetry as markers of preeclampsia.Dis Markers. 2011;30(4):191-6..

Downloads

Published

2015-06-24

How to Cite

Genovese, F., & Pafumi, C. (2015). Doppler Echo-flowmetry of the Uterine District and Peeclampsia. Asian Journal of Applied Sciences, 3(3). Retrieved from https://www.ajouronline.com/index.php/AJAS/article/view/741

Issue

Vol. 3 No. 3 (2015): June 2015

Section

Articles

License

  • Papers must be submitted on the understanding that they have not been published elsewhere (except in the form of an abstract or as part of a published lecture, review, or thesis) and are not currently under consideration by another journal published by any other publisher.
  • It is also the authors responsibility to ensure that the articles emanating from a particular source are submitted with the necessary approval.
  • The authors warrant that the paper is original and that he/she is the author of the paper, except for material that is clearly identified as to its original source, with permission notices from the copyright owners where required.
  • The authors ensure that all the references carefully and they are accurate in the text as well as in the list of references (and vice versa).
  • Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Attribution-NonCommercial 4.0 International that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  • Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  • Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
  • The journal/publisher is not responsible for subsequent uses of the work. It is the author's responsibility to bring an infringement action if so desired by the author.