Anatomical Justification for the Use of Human Placenta as a Host for in Vivo Cell and Tissue Transplantation

Authors

  • Ann Kakabadze 1. Ilia State University 2. Tbilisi State Medical University
  • Lika Karalashvili 1. Ilia State University 2. Tbilisi State Medical University
  • Malkhaz Makashvili Ilia State Univesity
  • Ivane Abiatari 1. Ilia State University 2. Tbilisi State Medical University
  • Zurab Kakabadze 1. Ilia State University 2. Tbilisi State Medical University 3.Georgian National Institute of Medical Research,

Keywords:

human placenta, transplantation, auxiliary organ, vascularization, anastomoses

Abstract

Authors provide anatomical justification for the use of human placenta as a host for transplanted cells and tissues. Full-term placentas from human donors was prepared for macroscopic visualization. Formalin prepared human cadavers were investigated to identify the optimal site for placenta transplantation. Umbilical vessels of the placenta can provide vascularization of the graft in the body of the recipient and the access of transplant to blood circulation for nutrient delivery and waste removal. The length and the diameter of the placenta arteries and veins provide formation of anastomoses between the placenta and recipient’s body. Vascularization of the graft in the body of the recipient can be provided without tension, torsion or inflection of anastomoses. The right iliac site is suggested optional for temporary heterotopic connection of the graft to the body of the recipient, while the hypochondriac and subhepatic regions can be advantageous for the linkage to portal and caval venous systems. Human placenta is suggested appropriate host for auxiliary organ creation.

 

Author Biographies

Ann Kakabadze, 1. Ilia State University 2. Tbilisi State Medical University

1. Center of Stem Cells and Tissue Bioengineering

2. Clinical Anatomy dpt.

Lika Karalashvili, 1. Ilia State University 2. Tbilisi State Medical University

1. Center of Stem Cells and Tissue Bioengineering

2. Clinical Anatomy dpt.

Malkhaz Makashvili, Ilia State Univesity

Institute of Apoplied psychology

Ivane Abiatari, 1. Ilia State University 2. Tbilisi State Medical University

1. Center of Stem Cells and Tissue Bioengineering

2. Clinical Anatomy dpt.

Zurab Kakabadze, 1. Ilia State University 2. Tbilisi State Medical University 3.Georgian National Institute of Medical Research,

1. Center of Stem Cells and Tissue Bioengineering

2. Clinical Anatomy dpt.

References

Alberti C., Hollow organ tissue engineering: short updating about current approaches and forecast for major research advances, Giornal e Chirurgia, 32, pp. 345-35, 2011.

Berishvili E, Liponava E, Kochlavashvili N, Kalandarishvili K, Benashvili L,Gupta S, Kakabadze Z., Heterotopic auxiliary liver in an isolated and vascularized segment of the small intestine in rats, Transplantation, 75, 1827-32, 2003.

Carraro A., Hsu WM, Kulig KM, Cheung WS, Miller ML, Weinberg EJ, Swart EF, Kaazempur-Mofr pp. ad M, Borenstein JT, Vacanti JP, Neville C., In vitro analysis of a hepatic device with intrinsic microvascular-based channels.Biomed. Microdevices, 10, pp. 795–805, 2008.

Carvalho J., Carvalho P., Gomes D., de Goes A., Innovative Strategies for Tissue Engineering , "Advances in Biomaterials Science and Biomedical Applications", R. Pignatello Publ., 2013.

Chung S, King MW., Design concepts and strategies for tissue engineering scaffolds, Biotechnol. Appl. Biochem., 58, pp. 423–438, 2011.

Dantzer V., Leiser R., Kaufmann P.,Luckhardt, M., Comparative morphological aspects of placental nascularisation,Trophoblast Res., 3, pp. 221–244. 1988.

Faber JJ, Thornburg KL., Placental Physiology. Structure and Function of Fetomaternal Exchange, Raven Press, 1983.

Flynn L, Semple JL, Woodhouse KA. Decellularized placental matrices for adipose tissue engineering, J. Biomed. Mater.Res., 79, pp. 359–369, 2006.

Ji Suk Choi, Jae Dong Kim, Hyun Soo Yoon, Yong Woo Cho, Full-Thickness Skin Wound Healing Using Human Placenta-Derived Extracellular Matrix Containing Bioactive Molecules, Tissue Engineering: Part A, V. 19, 3 and 4, 2013.

Joseph B, Berishvili E, Benten D, Kumaran V, Liponava E, Bhargava K, Palestro C, Kakabadze Z, Gupta S., Isolated small intestinal segments support auxiliary livers with maintenance of hepatic functions, Nat Med., 10, pp. 749-753, 2004

Kakabadze Z., Benashvili L., Berishvili E., The intracorporeal autoorganic biofilter of portal blood in portal hypertension surgery, Hepatogastroenterology, 48, pp. 752-756, 2001

Kakabadze Z., Gupta S., Brandhorst D., Korsgren O., Berishvili E. Long-term engraftment and function of transplanted pancreatic islets in vascularized segments of small intestine, Transpl. Int., 24., pp. 175-183, 2011.

Kakabadze Z., Gupta S., Pileggi A., Molano R., Ricordi C., Shatirishvili G., Loladze G., Mardaleishvili K., Kakabadze M., Berishvili E., Correction of diabetes mellitus by transplanting minimal mass of syngeneic islets into vascularized small intestinal segment, Am. J. Transplant, 13, pp. 2550-2557, 2013.

Kaufmann, P. Placentation und Placenta. In: Human-Embryologie, Springer-Verlag, Berlin, pp. 159–204, 1990.

Kulig KM, Vacanti JP., Hepatic tissue engineering, Transpl. Immunol., 12 pp. 303–310, 2004.

Navarro-Alvarez N, et al. Intramuscular transplantation of engineered hepatic tissue constructs corrects acute and chronic liver failure in mice. J. Hepatol., pp. 52:211–219, 2010.

Nuffield Council on Bioethics, Human Tissue Ethical and Legal Issues, Nuffield Council on Bioethics Publ., Great Brittain, 1995.

Uygun B., Yarmush M., Uygun K. Application of whole-organ tissue engineering in hepatology, 2012.

Yokoyama T., Ohashi K., Kuge H., Kanehiro H., Iwata H.,Yamato M.,Nakajima Y.,In vivo engineering of metabolically active hepatic tissues in a neovascularized subcutaneous cavity, Am. J. Transplant., 6, pp. 50–59, 2006.

Downloads

Published

2014-02-18

How to Cite

Kakabadze, A., Karalashvili, L., Makashvili, M., Abiatari, I., & Kakabadze, Z. (2014). Anatomical Justification for the Use of Human Placenta as a Host for in Vivo Cell and Tissue Transplantation. Asian Journal of Pharmacy, Nursing and Medical Sciences, 2(1). Retrieved from https://www.ajouronline.com/index.php/AJPNMS/article/view/911

Issue

Vol. 2 No. 1 (2014): February 2014

Section

Articles

License

  • Papers must be submitted on the understanding that they have not been published elsewhere (except in the form of an abstract or as part of a published lecture, review, or thesis) and are not currently under consideration by another journal published by any other publisher.
  • It is also the authors responsibility to ensure that the articles emanating from a particular source are submitted with the necessary approval.
  • The authors warrant that the paper is original and that he/she is the author of the paper, except for material that is clearly identified as to its original source, with permission notices from the copyright owners where required.
  • The authors ensure that all the references carefully and they are accurate in the text as well as in the list of references (and vice versa).
  • Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Attribution-NonCommercial 4.0 International that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  • Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  • Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
  • The journal/publisher is not responsible for subsequent uses of the work. It is the author's responsibility to bring an infringement action if so desired by the author.