Determination of Radiosurgery Treatment Volume for Intracranial Germ Cell Tumors (GCTS)

Authors

  • Murat Beyzadeoglu Department of Radiation Oncology; University of Health Sciences, Gulhane Medical Faculty, Ankara, Turkey
  • Ferrat Dincoglan Department of Radiation Oncology; University of Health Sciences, Gulhane Medical Faculty, Ankara, Turkey
  • Omer Sager Associate Professor of Radiation Oncology University of Health Sciences, Gulhane Medical Faculty, Department of Radiation Oncology. Gn.Tevfik SaÄŸlam Cd. Etlik , Ankara
  • Selcuk Demiral Department of Radiation Oncology; University of Health Sciences, Gulhane Medical Faculty, Ankara, Turkey

DOI:

https://doi.org/10.24203/ajpnms.v8i3.6120

Keywords:

germ cell tumor (GCT), stereotactic radiosurgery (SRS), target volume, magnetic resonance imaging (MRI)

Abstract

Background: Radiation therapy (RT) volumes for intracranial germ cell tumors (GCTs) may include focal treatment volumes, whole ventricle irradiation, whole brain irradiation, or irradiation of the entire neuroaxis. RT doses and volumes for management of primary intracranial GCTs have been an area of active research over the years. Improved sparing of critical organs by use of less extensive RT volumes and lower doses has been investigated for avoiding excessive morbidity of treatment. Herein, we assess intracranial GCT treatment volume determination.

Methods: Treatment volume definition for intracranial GCT by incorporation of Magnetic Resonance Imaging (MRI) was comparatively assessed in our study. Reference volume for comparison purposes was defined after thorough assessment and collaboration of the board certified radiation oncologists. Definition of radiosurgery target volume was based solely on CT images or fusion of CT with MRI. Comparative evaluation of treatment volume determination was performed.

Results: Ground truth target volume defined after thorough evaluation and collaboration of the board certified radiation oncologists was similar with treatment volume definition based on CT-MR fusion based imaging.

Conclusions: In conclusion, radiosurgery treatment planning for intracranial GCTs may be improved by incorporation of MRI into target definition process. Clearly, further studies are warranted to draw firm conclusions on optimal target definition for intracranial GCT radiosurgery.

 

References

Ostrom QT, Gittleman H, Truitt G, Boscia A, Kruchko C, Barnholtz-Sloan JS. CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2011-2015. Neuro Oncol. vol. 20, no. (suppl_4), pp. iv1-iv86, 2018.

Wong TT, Ho DM, Chang KP, Yen SH, Guo WY, Chang FC, Liang ML, Pan HC, Chung WY. Primary pediatric brain tumors: statistics of Taipei VGH, Taiwan (1975-2004). Cancer. vol. 104, no. 10, pp. 2156-2167, 2005.

Lee CH, Jung KW, Yoo H, Park S, Lee SH. Epidemiology of primary brain and central nervous system tumors in Korea. J Korean Neurosurg Soc. vol. 48, no. 2, pp. 145-152, 2010.

Hardenbergh PH, Golden J, Billet A, Scott RM, Shrieve DC, Silver B, Loeffler JS, Tarbell NJ. Intracranial germinoma: the case for lower dose radiation therapy. Int J Radiat Oncol Biol Phys. vol. 39, no. 2, pp. 419-426, 1997.

Nguyen QN, Chang EL, Allen PK, Maor MH, Ater JL, Mahajan A, Wolff JE, Weinberg JS, Woo SY. Focal and craniospinal irradiation for patients with intracranial germinoma and patterns of failure. Cancer. vol. 107, no. 9, pp. 2228-2236, 2006.

Cho J, Choi JU, Kim DS, Suh CO. Low-dose craniospinal irradiation as a definitive treatment for intracranial germinoma. Radiother Oncol. vol 91, no. 1, pp. 75-79, 2009.

Chen YW, Huang PI, Ho DM, Hu YW, Chang KP, Chiou SH, Guo WY, Chang FC, Liang ML, Lee YY, Chen HH, Hsu TR, Lin SC, Wong TT, Yen SH. Change in treatment strategy for intracranial germinoma: long-term follow-up experience at a single institute. Cancer. vol. 118, no. 10, pp. 2752-2762, 2012.

Kim JY, Park J. Understanding the Treatment Strategies of Intracranial Germ Cell Tumors: Focusing on Radiotherapy. J Korean Neurosurg Soc. vol. 57, no. 5, pp. 315-322, 2015.

Rogers SJ, Mosleh-Shirazi MA, Saran FH. Radiotherapy of localised intracranial germinoma: time to sever historical ties? Lancet Oncol. vol. 6, no. 7, pp. 509-519, 2005.

Jensen AW, Laack NN, Buckner JC, Schomberg PJ, Wetmore CJ, Brown PD. Long-term follow-up of dose-adapted and reduced-field radiotherapy with or without chemotherapy for central nervous system germinoma. Int J Radiat Oncol Biol Phys. vol. 77, no. 5, pp. 1449-1456, 2010.

Bamberg M, Kortmann RD, Calaminus G, Becker G, Meisner C, Harms D, Göbel U. Radiation therapy for intracranial germinoma: results of the German cooperative prospective trials MAKEI 83/86/89. J Clin Oncol. vol. 17, no. 8, pp. 2585-2892, 1999.

Kortmann R, Worch J, Nicholson JC, Alapetite C, Garrè ML, Patte C, Ricardi U, Saran F, Frappaz D. SIOP CNS GCT 96: final report of outcome of a prospective, multinational nonrandomized trial for children and adults with intracranial germinoma, comparing craniospinal irradiation alone with chemotherapy followed by focal primary site irradiation for patients with localized disease. Neuro Oncol. vol. 15, no. 6, pp. 788-796, 2013.

Dincoglan F, Beyzadeoglu M, Sager O, Uysal B, Demiral S, Gamsiz H, Dirican B. Evaluation of linear accelerator-based stereotactic radiosurgery in the management of meningiomas: a single center experience. J BUON, vol. 18, no. 3, pp. 717-722, 2013.

Sager O, Beyzadeoglu M, Dincoglan F, Uysal B, Gamsiz H, Demiral S, Oysul K, Dirican B, Sirin S. Evaluation of linear accelerator (LINAC)-based stereotactic radiosurgery (SRS) for cerebral cavernous malformations: a 15-year single-center experience. Ann Saudi Med, vol. 34, no. 1, pp. 54-58, 2014.

Sager O, Beyzadeoglu M, Dincoglan F, Gamsiz H, Demiral S, Uysal B, Oysul K, Dirican B, Sirin S. Evaluation of linear accelerator-based stereotactic radiosurgery in the management of glomus jugulare tumors. Tumori, vol. 100, no. 2, pp. 184-188, 2014.

Gamsiz H, Beyzadeoglu M, Sager O, Dincoglan F, Demiral S, Uysal B, Surenkok S, Oysul K, Dirican B. Management of pulmonary oligometastases by stereotactic body radiotherapy. Tumori, vol. 100, no. 2, pp. 179-183, 2014.

Dincoglan F, Sager O, Gamsiz H, Uysal B, Demiral S, Oysul K, Sirin S, Caglan A, Beyzadeoglu M. Management of patients with ≥4 brain metastases using stereotactic radiosurgery boost after whole brain irradiation. Tumori, vol. 100, no. 3, pp. 302-306, 2014.

Demiral S, Beyzadeoglu M, Sager O, Dincoglan F, Gamsiz H, Uysal B, Oysul K, Gundem E, Dirican B, Sirin S. Evaluation of Linear Accelerator (Linac)-Based Stereotactic Radiosurgery (Srs) for the Treatment of Craniopharyngiomas. Int J Hematol Oncol, vol. 24, no. 2, pp. 123-129, 2014.

Gamsiz H, Beyzadeoglu M, Sager O, Demiral S, Dincoglan F, Uysal B, Onal E, Dirican B. Evaluation of stereotactic body radiation therapy in the management of adrenal metastases from non-small cell lung cancer. Tumori, vol. 101, no. 1, pp. 98-103, 2015.

Sager O, Dincoglan F, Beyzadeoglu M. Stereotactic radiosurgery of glomus jugulare tumors: current concepts, recent advances and future perspectives. CNS Oncol, vol. 4, no. 2, pp. 105-114, 2015.

Dincoglan F, Beyzadeoglu M, Sager O, Demiral S, Gamsiz H, Uysal B, Ebruli C, Akin M, Oysul K, Sirin S, Dirican B. Management of patients with recurrent glioblastoma using hypofractionated stereotactic radiotherapy. Tumori, vol. 101, no. 2, pp. 179-184, 2015.

Demiral S, Dincoglan F, Sager O, Gamsiz H, Uysal B, Gundem E, Elcim Y, Dirican B, Beyzadeoglu M. Hypofractionated stereotactic radiotherapy (HFSRT) for who grade I anterior clinoid meningiomas (ACM). Jpn J Radiol, vol. 34, no. 11, pp. 730-737, 2016.

Dincoglan F, Sager O, Demiral S, Uysal B, Gamsiz H, Dirican B, Beyzadeoglu M. Radiosurgery for recurrent glioblastoma: a review article. Neurol Disord Therap, vol.1, no. 4, pp. 1-5, 2017.

Demiral S, Dincoglan F, Sager O, Uysal B, Gamsiz H, Ozcan F, Dirican B, Beyzadeoglu M. Contemporary Management of Meningiomas with Radiosurgery. Int J Radiol Imaging Technol, vol. 4, pp. 041, 2018.

Dincoglan F, Sager O, Demiral S, Uysal B, Gamsiz H, Dirican B, Beyzadeoglu M. Radiosurgery for recurrent glioblastoma: A review article. Neurol Disord Therap. vol. 1, pp. 1-5.

Dincoglan F, Sager O, Uysal B, Demiral S, Gamsiz H, Gündem E, Elcim Y, Dirican B, Beyzadeoglu M. Evaluatıon of hypofractıonated stereotactıc radıotherapy (HFSRT) to the resectıon cavıty after surgıcal resectıon of braın metastases: A sıngle center experıence. Indian J Cancer. vol. 56, no. 3, pp. 202-206, 2019.

Dincoglan F, Sager O, Demiral S, Gamsiz H, Uysal B, Onal E, Ekmen A, Dirican B, Beyzadeoglu M. Fractionated stereotactic radiosurgery for locally recurrent brain metastases after failed stereotactic radiosurgery. Indian J Cancer. vol. 56, no. 2, pp. 151-156, 2019.

Dincoglan F, Beyzadeoglu M, Sager O, Demiral S, Uysal B, Gamsiz H, Colak A, Ozcan F, Dirican B. A Concise Review of Irradiation for Temporal Bone Chemodectomas (TBC). Arch Otolaryngol Rhinol. vol 6, no. 2, pp. 016-020, 2020.

Hu YW, Huang PI, Wong TT, Ho DM, Chang KP, Guo WY, Chang FC, Shiau CY, Liang ML, Lee YY, Chen HH, Yen SH, Chen YW. Salvage treatment for recurrent intracranial germinoma after reduced-volume radiotherapy: a single-institution experience and review of the literature. Int J Radiat Oncol Biol Phys. vol. 84, no. 3, pp. 639-647, 2012.

Wong K, Opimo AB, Olch AJ, All S, Waxer JF, Clark D, Cheng J, Chlebik A, Erdreich-Epstein A, Krieger MD, Tamrazi B, Dhall G, Finlay JL, Chang EL. Re-irradiation of Recurrent Pineal Germ Cell Tumors with Radiosurgery: Report of Two Cases and Review of Literature. Cureus. vol. 8, no. 4, pp. e585, 2016.

Yang QY, Guo CC, Deng ML, Wang J, Wang J, Lin FH, Zhang J, Jiang XB, Mou YG, Chen ZP. Treatment of primary intracranial germ cell tumors: Single center experience with 42 clinically diagnosed cases. Oncotarget. vol. 7, no. 37, pp. 60665-60675, 2016.

Sager O, Beyzadeoglu M, Dincoglan F, Oysul K, Kahya YE, Gamsiz H, Uysal B, Demiral S, Dirican B, Surenkok S. Evaluation of active breathing control-moderate deep inspiration breath-hold in definitive non-small cell lung cancer radiotherapy. Neoplasma. Vol. 59, no. 3, pp. 333-340, 2012.

Dincoglan F, Beyzadeoglu M, Sager O, Oysul K, Kahya YE, Gamsiz H, Uysal B, Demiral S, Dirican B, Surenkok S. Dosimetric evaluation of critical organs at risk in mastectomized left-sided breast cancer radiotherapy using breath-hold technique. Tumori. vol. 99, no. 1, pp. 76-82, 2013.

Uysal B, Beyzadeoğlu M, Sager O, Dinçoğlan F, Demiral S, Gamsız H, Sürenkök S, Oysul K. Dosimetric evaluation of intensity modulated radiotherapy and 4-field 3-d conformal radiotherapy in prostate cancer treatment. Balkan Med J. vol. 30, no. 1, pp. 54-57, 2013.

Sager O, Beyzadeoglu M, Dincoglan F, Demiral S, Uysal B, Gamsiz H, Akin M, Gundem E, Dirican B. Adaptive splenic radiotherapy for symptomatic splenomegaly management in myeloproliferative disorders. Tumori. vol. 101, no. 1, pp. 84-90, 2015.

Sager O, Dincoglan F, Uysal B, Demiral S, Gamsiz H, Beyzadeoglu M. Splenic Irradiation: A Concise Review of the Literature. J App Hem Bl Tran. Vol. 1, no. 1, pp. 101, 2017.

Sager O, Dincoglan F, Uysal B, Demiral S, Gamsiz H, Elcim Y, Gundem E, Dirican B, Beyzadeoglu M. Evaluation of adaptive radiotherapy (ART) by use of replanning the tumor bed boost with repeated computed tomography (CT) simulation after whole breast irradiation (WBI) for breast cancer patients having clinically evident seroma. Jpn J Radiol. vol. 36, no. 6, pp. 401-406, 2018.

Sager O, Dincoglan F, Demiral S, Uysal B, Gamsiz H, Ozcan F, Colak O, Elcim Y, Dirican B, Beyzadeoglu M. Breathing adapted radiation therapy for leukemia relapse in the breast: A case report. World J Clin Oncol. vol. 10, no. 11, pp. 369-374, 2019.

Demiral S, Sager O, Dincoglan F, Beyzadeoglu M. Assessment of Computed Tomography (CT) And Magnetic Resonance Imaging (MRI) Based Radiosurgery Treatment Planning for Pituitary Adenomas. Canc Therapy & Oncol Int J. vol 13, no. 2, pp. 555857, 2019.

Beyzadeoglu M, Sager O, Dincoglan F, Demiral S. Evaluation of Target Definition for Stereotactic Reirradiation of Recurrent Glioblastoma. Arch Can Res. vol 7, no. 1, pp. 3, 2019.

Sager O, Dincoglan F, Demiral S, Beyzadeoglu M. Evaluation of Radiosurgery Target Volume Determination for Meningiomas Based on Computed Tomography (CT) And Magnetic Resonance Imaging (MRI) Cancer Sci Res Open Access. vol 5, no. 2, pp. 1-4, 2019.

Dincoglan F, Sager O, Demiral S, Beyzadeoglu M. Multimodality Imaging for Radiosurgical Management of Arteriovenous Malformations. Asian Journal of Pharmacy, Nursing and Medical Sciences. vol. 7, no. 1, pp. 7-12, 2019.

Demiral S, Sager O, Dincoglan F, Beyzadeoglu M. Assessment of target definition based on Multimodality imaging for radiosurgical Management of glomus jugulare tumors (GJTs). Canc Therapy & Oncol Int J. vol. 15, no. 2, pp. 555909, 2019.

Sager O, Dincoglan F, Demiral S, Gamsiz H, Uysal B, Dirican B, Beyzadeoglu M. Utility of Magnetic Resonance Imaging (Imaging) in Target Volume Definition for Radiosurgery of Acoustic Neuromas. Int J Cancer Clin Res. vol. 6, no. 3, pp. 119, 2019.

Sager O, Dincoglan F, Demiral S, Gamsiz H, Uysal B, Ozcan F, Colak O, Dirican B, Beyzadeoglu M. Evaluation of the Impact of Magnetic Resonance Imaging (MRI) on Gross Tumor Volume (GTV) Definition for Radiation Treatment Planning (RTP) of Inoperable High Grade Gliomas (HGGs). Concepts in Magnetic Resonance Part A. vol 2019, pp. 1-7, Article ID 4282754, 2019.

Demiral S, Sager O, Dincoglan F, Uysal B, Gamsiz H, Dirican B, Beyzadeoglu M. Evaluation of Target Volume Determination for Single Session Stereotactic Radiosurgery (SRS) of Brain Metastases. Canc Therapy & Oncol Int J. vol. 12, no. 5, pp. 555848, 2018.

Sager O, Demiral S, Dincoglan F, Beyzadeoglu M. Target Volume Definition for Stereotactic Radiosurgery (SRS) Of Cerebral Cavernous Malformations (CCMs). Canc Therapy & Oncol Int J. vol. 15, no. 4, pp. 555917, 2020.

Dincoglan F, Demiral S, Sager O, Beyzadeoglu M. Utility of Multimodality Imaging Based Target Volume Definition for Radiosurgery of Trigeminal Neuralgia: An Original Article. Biomed J Sci & Tech Res. vol. 26, no. 2, pp. 19728-19732, 2020.

Sager O, Dincoglan F, Demiral S, Beyzadeoglu M. Radiosurgery Treatment Volume Determination for Brain Lymphomas with and without Incorporation of Multimodality Imaging. Journal of Medical Pharmaceutical and Allied Sciences. vol. 9, no. 1, pp. 2398-2404, 2020.

Beyzadeoglu M, Dincoglan F, Demiral S, Sager O. Target Volume Determination for Precise Radiation Therapy (RT) of Central Neurocytoma: An Original Article. International Journal of Research Studies in Medical and Health Sciences. vol. 5, no. 3, pp. 29-34, 2020.

Demiral S, Beyzadeoglu M, Dincoglan F, Sager O. Assessment of Target Volume Definition for Radiosurgery of Atypical Meningiomas with Multimodality Imaging. Journal of Hematology and Oncology Research. vol. 3, no. 4, pp. 14-21, 2020.

Published

2020-06-30

How to Cite

Beyzadeoglu, M., Dincoglan, F., Sager, O., & Demiral, S. (2020). Determination of Radiosurgery Treatment Volume for Intracranial Germ Cell Tumors (GCTS). Asian Journal of Pharmacy, Nursing and Medical Sciences, 8(3). https://doi.org/10.24203/ajpnms.v8i3.6120

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Articles