Fabrication of Magnetic Nanocomposites Using Natural Polymer Coating to Grain and Ciprofloxacin


  • Farzad Soleymani Department of Engineering, Payame Noor University (PNU) Tehran, Iran




Magnetic nanoparticles; Natural Polymer; Physicochemical; Antibacterial property


In this study, we try to stabilize magnetic nanoparticles (Fe3O4) with natural granular polymer (granular mucilage as a natural, biocompatible and biodegradable coating) and then load the drug ciprofloxacin on these nanoparticles. Then, structural, magnetic, physicochemical, colloidal and antibacterial properties of the samples using various characterization tools and tests such as X-ray diffraction (XRD) analysis, transmission electron microscopy (TEM) analysis, FEE-SEM field scanning electron microscopy (SEM) Vibrating Sample Magnetometry (VSM), Infrared Fourier Analysis (FTIR), Optical Spectroscopy (UV-Vis), Dynamic Light Scattering (DLS), Nanoparticle Specific Surface (BET) and Testing The antibacterial property of disk diffusion must be investigated [21]. XRD results as well as structural analysis of the samples confirm the magnetite phase with high purity. The results of FE-SEM and TEM analyzes indicate spherical morphology and very small size of magnetite nanoparticles (average 13 nm). The results of DLS analysis show a hydrodynamic diameter of 81.9 to 119.2 nm for magnetic nanoparticles with different structures. Zeta potential values ​​for magnetic nanoparticles are between -0.28 and -55.2 mV, indicating suitable colloidal stability of the nanoparticles for biological applications. The VSM results indicate the high saturation magnetization of the samples as well as the small amounts of the forcing field and the residual magnetization of the samples, which indicates the superpromagnetic property of the nanoparticles.


M. Arruebo, R. Fernández-Pacheco, M. R. Ibarra and J. Santamaría, "Magnetic nanoparticles for drug delivery," Nano today, vol. 2, no. 3, pp. 22-32, 2007.

K. J. Widder, A. E. Senyei and D. G. Scarpelli, "Magnetic microspheres: a model system for site specific drug delivery in vivo," Proceedings of the Society for Experimental Biology and Medicine, vol. 158, no. 2, pp. 141-146, 1978.

M. Ashjari, S. Khoee and A. R. Mahdavian, "Controlling the morphology and surface property of magnetic/cisplatin-loaded nanocapsules via W/O/W double emulsion method," Colloids and Surfaces A: Physicochemical and Engineering Aspects, vol. 408, pp. 87-96, 2012.

M. Filippousi et al., "Novel core–shell magnetic nanoparticles for Taxol encapsulation in biodegradable and biocompatible block copolymers: Preparation, characterization and release properties," International journal of pharmaceutics, vol. 448, no. 1, pp. 221-230, 2013.

E. Rasouli et al., "Facile and greener hydrothermal honey‐based synthesis of Fe_3 O_4/Au core/shell nanoparticles for drug delivery applications," Journal of cellular biochemistry, vol. 120, no. 4, pp. 6624-6631, 2019.

A. Rayegan, A. Allafchian, I. A. Sarsari, and P. Kameli, "Synthesis and characterization of basil seed mucilage coated Fe3O4 magnetic nanoparticles as a drug carrier for the controlled delivery of cephalexin," International journal of biological macromolecules, vol. 113, pp. 317-328, 2018.

S. Kariminia, A. Shamsipur and M. Shamsipur, "Analytical characteristics and application of novel chitosan coated magnetic nanoparticles as an efficient drug delivery system for ciprofloxacin. Enhanced drug release kinetics by low-frequency ultrasounds," Journal of pharmaceutical and biomedical analysis, vol. 129, pp. 450-457, 2016.

N. Saxena and M. Singh "Efficient synthesis of superparamagnetic magnetite nanoparticles under air for biomedical applications," Journal of Magnetism

M. Compeán-Jasso, F. Ruiz, J.R. Martínez, and A. Herrera-Gómez, "Magnetic properties of magnetite nanoparticles synthesized by forced hydrolysis," Materials Letters, vol. 62, no. 27, pp. 4248-4250, 2008.

R. Valenzuela et al., "Influence of stirring velocity on the synthesis of magnetite nanoparticles (Fe3O4) by the co-precipitation method," Journal of Alloys and Compounds, vol. 488, no. 1, pp. 227-231, 2009.

E. Alp and N. Aydogan, "A comparative study: synthesis of superparamagnetic iron oxide nanoparticles in air and N2 atmosphere," Colloids and Surfaces A: Physicochemical and Engineering Aspects, vol. 510, pp. 205-212, 2016.

L. Li et al., "Effect of synthesis conditions on the properties of citric-acid coated iron oxide nanoparticles," Microelectronic Engineering, vol. 110, pp. 329-334, 2013.

S. Laurent et al., "Magnetic iron oxide nanoparticles: synthesis, stabilization, vectorization, physicochemical characterizations, and biological applications," Chemical reviews, vol. 108, no. 6, pp. 2064-2110, 2008.

J. R. Correa, D. Canetti, R. Castillo, J. C. Llópiz, and J. Dufour, "Influence of the precipitation pH of magnetite in the oxidation process to maghemite," Materials research bulletin, vol. 41, no. 4, pp. 703-713, 2006.

Â. L. Andrade, D. M. Souza, M. C. Pereira, J. D. Fabris, and R. Z. Domingues, "pH effect on the synthesis of magnetite nanoparticles by the chemical reduction-precipitation method," Quimica Nova, vol. 33, no. 3, pp. 524-527, 2010.

W. Ramadan, M. Kareem, B. Hannoyer, and S. Saha, "Effect of pH on the structural and magnetic properties of magnetite nanoparticles synthesised by co-precipitation," Advanced Materials Research, 2011, vol. 324, pp. 129-132: Trans Tech Publ.

S. Rani and G. D. Varma, "Superparamagnetism and metamagnetic transition in Fe3O4 nanoparticles synthesized via co-precipitation method at different pH," Physica B: Condensed Matter, vol. 472, pp. 66-77, 2015.

A. Faiyas, E. Vinod, J. Joseph, R. Ganesan and R. K. Pandey "Dependence of pH and surfactant effect in the synthesis of magnetite (Fe3O4) nanoparticles and its properties," Journal of Magnetism and Magnetic Materials, vol. 322, no. 4, pp. 400-404, 2010.

M. Jouki, S. A. Mortazavi, F. T. Yazdi, and A. Koocheki, "Optimization of extraction, antioxidant activity and functional properties of quince seed mucilage by RSM," International journal of biological macromolecules, vol. 66, pp. 113-124, 2014.

A. Moghbel and M. Tayebi, "Quince Seed Lyophilized Biopolymer as a Medicinal Remedy: Study of Mechanical Properties of the Powder and Tablets," JUNDISHAPUR JOURNAL OF NATURAL PHARMACEUTICAL PRODUCTS, vol. 11, no. 1, 2016.

Shirazi, M. (1398). Natural Polymer Coating to Fabrication and Study of Magnetite Nanocomposites, IUT, Physics.

Shahsavari, Saeed, and Mehran Moradi. "A General Solution to the Different Formulations of the Second Law of Thermodynamics." Journal of Advanced Research in Fluid Mechanics and Thermal Sciences 82.2 (2021): 61-71.‏

Shahsavari, Saeed, Mehran Moradi, "A Study of the Entropy Production in Physical Processes from a New Perspective of the Energy Structure." Asian Journal of Applied Sciences (ISSN: 2321–0893) 8.6 (2020).‏

Shahsavari, Saeed, Mehran Moradi, and Morteza Esmaeilpour. "On the Irreversibility in Mechanical Systems Using a New Macroscopic Energy Structure Modeling." Asian Journal of Applied Sciences (ISSN: 2321–0893) 8.6 (2020).‏

Shahsavari, Saeed, Mehran Moradi, and Morteza Esmaeilpour. "On the Available Work Limits at Constant Heat and Entropy Production." Asian Journal of Applied Sciences (ISSN: 2321–0893) 8.6 (2020).‏

Shahsavari, Saeed, Mehran Moradi, " An Applied Component Modeling to the Irreversibility from a New Configurationally Perspective of the Statistical Physics." Asian Journal of Fuzzy and Applied Mathematics (ISSN: 2321 – 564X) 8.3 (2020).

Shahsavari, Saeed, Mehran Moradi, " Application of an Innovate Energy Balance to Investigate Viscoelastic Problems." Asian Journal of Engineering and Technology (ISSN: 2321 – 2462) 8.4 (2020).




How to Cite

Soleymani, F. (2023). Fabrication of Magnetic Nanocomposites Using Natural Polymer Coating to Grain and Ciprofloxacin. Asian Journal of Applied Sciences, 10(6). https://doi.org/10.24203/ajas.v10i6.7120