Spectroscopic Studies on the Binding of Some Fluoroquinolones with DNA


  • Ibrahim Abu-Shqair
  • Nizam Diab The Arab American university
  • Radi Salim
  • Mohammad Al-Subu


fluoroquinolone, DNA binding, Intercalation, UV-Visible Methods


UV-visible spectroscopic methods were used to study the interaction of some fluoroquinolones with calf-thymus DNA. The binding constants of drug-DNA complexes were evaluated and the nature of binding of these drugs with DNA were elucidated. The results suggested that fluoroquinolones bind to DNA through an electrostatic mode of interaction with partial intercalation.



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How to Cite

Abu-Shqair, I., Diab, N., Salim, R., & Al-Subu, M. (2013). Spectroscopic Studies on the Binding of Some Fluoroquinolones with DNA. Asian Journal of Applied Sciences, 1(5). Retrieved from https://www.ajouronline.com/index.php/AJAS/article/view/595