Oxidants and Antioxidants Status in Bronchial Asthma
Keywords:Bronchial asthma, antioxidants, vitamins, inflammation
Asthma is a respiratory disease that is common in Saudi Arabia and characterized by sporadic occurrence of bridge, chronic inflammation of the airways involving recurrent airflow obstruction and increased responsiveness to a variety of stimuli. Recent research suggests that airway inflammation is the most cause of the episodes of airflow limitation in asthma which lead to increase oxidative stress. This imbalance between oxidant and antioxidant has been increasingly recognized as a big factor contributing to the chronic inflammation. Therefore, the aim of this review is to describe the role and origin of the oxidant-antioxidant disturbances that participate in the pathophysiology of airway inflammatory diseases. We have updated existing information about effects (effects of oxidants in the lung) of reactive oxygen and nitrogen species in the lung including the mechanisms of their damaging effect. The first section focuses entirely on the symptoms, the types and stages of bronchial asthma. The second section investigates the role of oxidant-antioxidant imbalance in disease progression of asthma. The last section outlines the therapeutic value of available antioxidant herbals and vitamins that could improve oxidant-antioxidant balance in bronchial asthma disease.
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