Comparative Study on Effects of Watermelon and Orange on Glycemic Index, Histopathology and Body Weight Changes in Wistar Albino Rats Following Consumption


  • Erifeta O. Georgina
  • Kingsley Omage Department of Biochemistry, College of Basic Medical Sciences, Igbinedion University, Okada, Edo State, Nigeria.
  • Waliu A. Olamide


Glycemic index, histopathology, normal dose, necrosis, DOG, body weight


Glycemic index and histopathological effects of watermelon and orange, as well as their effect on body weight changes were studied on fed Wistar albino rats using varying doses of the juices. 120 g/70 kg body weight was used as the standard dose, and the animals were given the normal dose, × 1.5, and × 2.0 of the normal dose, orally, for a period of six weeks. Our results showed that watermelon caused a significant (p < 0.05) dose related increase in blood glucose, while orange caused a significant (p < 0.05) dose related decrease in blood glucose after three and six weeks of juice administration. The treatment also showed that orange juice caused a significant (p < 0.05) decrease in body weight than watermelon juice. Histopathological findings revealed complications which include necrosis of the liver and degeneration of the glomerular, with the incidence higher for watermelon than orange. These findings, however, make orange a better choice than watermelon for individuals ready to shed weight, and at the same time cautions against long time consumption or over indulgence in the consumption of these fruits, as it may be dangerous for health reasons as in view of the histopathological findings.



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How to Cite

Georgina, E. O., Omage, K., & Olamide, W. A. (2013). Comparative Study on Effects of Watermelon and Orange on Glycemic Index, Histopathology and Body Weight Changes in Wistar Albino Rats Following Consumption. Asian Journal of Applied Sciences, 1(4). Retrieved from