Synthesis of Some New Derivatives of 2-hydrazeno-benzo-thiazole 2-mercpto-benzothiazole and Used as Fungicide Agents
The formation of 2-mercpto -thiol-benzothiazole (C1)was prepared by refluxing the o-amino phenyl mercaptan with carbon disulfide, while the 2- mercpto-benzothiazole was reacted with 37% of formaldehyde to get 2- hydroxyl methyl thiol benzothiazole (C2). Oxime compound (C3) was synthesis through reaction of C1 with chloro acetic acid in presence of sodium hydroxide in ethanol, while the 2-hydrazino-benzonitro-thiazole (C4) was prepared by mixing the C3 with chloroform and para methyl benzoic acid. 1, 2, 4-oxadizole (C5) was prepared by heating the C4 at 100-110 O cand recrystallization from benzene and petroleum ether. The synthesized compounds have been characterized on the basis of IR spectral analysis and the results are compatible with their assigned structures. Derivative compounds syntheses were experienced in vitro for their antifungal activity against Alternaria alternata, Fusarium oxysporium and Verticilliumdahliae, and in the field used the Cucurbita pepo L., as moderate plant. The results indicated that the derivatives compounds were have a good level of inhibitions for fungus species.
â€¢ Arpana, R. ; N. Siddiqui, and S. A. Khan (2007). Benzothiazoles: A New Profile of Biological Activities. Indian J. Pharma. Sci., 69:10-17.
â€¢ Barry, A. (1991). Procedures and theoretical considerations for testing antimicrobial agents in agar media, in: Lorian (Ed.), Antibiotics in laboratory medicine, 5th Ed. Williams and Wilkins, Baltimore (MD).
â€¢ Berge's Manual of Systematic Bacteriology. (2002). Williams and Wilkins. Baltimore. Vol. 2. MD21202. U.S.A. 1208 - 1232.
â€¢ Catriona, G. M., G. W. J. Crochard, E. L. Stone, T. D. Bradshaw, M. F. G. Stevens, and A. D. Westwell (2006). Antitumor Benzothiazoles. 26.1 2-(3, 4-Dimethoxyphenyl)-5-fluorobenzothiazole (GW 610, NSC, 721648), a Simple Fluorinated 2-Arylbenzothiazole, Shows Potent and Selective Inhibitory. Activity against Lung, Colon, and Breast Cancer Cell Lines. J. Med. Chem., 49: 179-185.
â€¢ Clark. A.L. (1982). "Preparation of 2-amino Benzothiazole" U. S. patent, No. 4, 363, 913.
â€¢ Demas, F. ; A. Arellaneda, and C. Digiorgio (2004). "Synthesis and antileishmanial activity of (1, 3-benzothiazole-2-yl) amino-9-(10H) acridinone derivatives". European Journal chemistry, 39, 685-690.
â€¢ Dong-Fang, S. ; Bradshaw, T.D. ; Wrigley, S. ; McCall, C. J. 1996. J. of Med. Chem. 39: 3375-3387.
â€¢ Dubey A. and N. Sangwan (1994). Synthesis and antifungal activity of 5-(3, 5-diphenyl pyrazole-4-yl oxy-methyl)-2-(4-oxa-2-substituted phenyl-3-thiazolidinyl)-1, 3, 4-oxadiazoles thiadiazoles and related compounds. Indian J. Chem., Sect. B. 33:1043â€“1047.
â€¢ Goswami B.N.; J.C.S. Kataky and J.N. Baruash (1984). Synthesis of 3, 4-disubstituted 1, 3, 4-oxadiazole-2-thiones as potential fungicidal agents. J. Heterocyclic. Chem., 21: 205â€“208.
â€¢ Kaur, H., Kumar, S. , Singh, I., Saxena, K.K. and Kumar, A. 2010. Synthesis, Characterization and Biological activity of various substituted benathiazole derivatives. Digest J. Nanomaterials and Biostructures. 5(1): 67-76.
â€¢ Maslat, A.O. ; M. Abussaud, H. Tashtoush and M. Al-Talib (2002). Synthesis, Antibacterial, Antifungal and Genotoxic Activities of Bis-1, 3, 4,-oxadiazole derivatives. Pol. J. pharmacol. 54:55-59.
â€¢ Papakonstantinou G.S.; P. Markos, K.A.Tsantili, and L.A.Chytyroglon (1998). Synthesis, liophilicity and antimicrobial properties of some o-(5-aryl-1, 2, 4-triazol-3-yl-ethyl) benzaldoximes and o-(5-aryl-1, 2, 4-oxadiazole-2-yl-ethyl) benzaldoximes. Pharmacia, 53; 300â€“302.
â€¢ Rajeeva, B. Srinivasula N. and Shantakumar, S.M. 2009. Synthesis and antimicrobial activity of some new 2-substituted benzathiazole derivatives. E.J. Chem., 6(3): 775-779.
â€¢ Shah V.R.; M. Vadodaria, and A.R. Parikh (1997). Synthesis of 1, 3, 4-oxadiazoles having nicotinamide moiety as potential antimicrobial agents. Indian J. Chem., 36: 101â€“103.
â€¢ Talawr M.B. ; S.R. Dejai, Y.S. Sommanavar, S.C. Marihal, and S.C. Bennur: (1996). Synthesis and antimicrobial activity of 1, 2, 4-triazoles, 1, 3, 4-oxadiazdoles and 1, 3, 4-thiadiazoles. Indian J. Heterocyclic. Chem., 5: 215â€“218.
â€¢ Verma, R.S. (1998). Antifungal agents: past, present and future prospects, national Academy of chemistry and biology, Lucknow, India.
â€¢ Winn, C.W., D.S. Allen M.W. Janda W.E. Koneman W.G. Procop C.P. Schreckenberger and L.G. Woods (2006). Koneman's Color Atlas and Textbook of Diagnostic Microbiology. Sixth Edition, Lippincott Williams Wilkins.
How to Cite
- Papers must be submitted on the understanding that they have not been published elsewhere (except in the form of an abstract or as part of a published lecture, review, or thesis) and are not currently under consideration by another journal published by any other publisher.
- It is also the authors responsibility to ensure that the articles emanating from a particular source are submitted with the necessary approval.
- The authors warrant that the paper is original and that he/she is the author of the paper, except for material that is clearly identified as to its original source, with permission notices from the copyright owners where required.
- The authors ensure that all the references carefully and they are accurate in the text as well as in the list of references (and vice versa).
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Attribution-NonCommercial 4.0 International that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
- The journal/publisher is not responsible for subsequent uses of the work. It is the author's responsibility to bring an infringement action if so desired by the author.