Insight into Control Architecture of Skin Pathology and Skin Penetration by Mathematical Modeling: an Introduction for Non-mathematicians
Keywords:Mathematical modeling, Atopic dermatitis, psoriasis, , transdermal drug delivery
AbstractMathematical modeling involves construction of a set of equations or description of a stochastic process closely mimicking a real phenomenon of practical significance and biological or physiological relevance. This paper reviews some specific pathological conditions of the skin and permeation of drugs across the skin during topical administration and transdermal route of delivery in the light of mathematical modeling. It aims at providing an insight into different variables governing any pathological situation of the skin involving a complex architecture of chemical mediators. The factors controlling skin permeability of a drug molecule have also been studied. The final outcome of the paper is to equip non-mathematicians with simple mathematical tools to conduct real experiments in a more satisfactory manner and explain the physiological phenomena in a robust fashion.
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